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ISO 17735:2019 Workplace atmospheres - Determination of total isocyanate groups in air using 1-(9-anthracenylmethyl)piperazine (MAP) reagent and liquid chromatography >
ISO 17735:2019 Workplace atmospheres - Determination of total isocyanate groups in air using 1-(9-anthracenylmethyl)piperazine (MAP) reagent and liquid chromatography, 2019
- Foreword
- Introduction
- 1 Scope
- 2 Normative references
- 3 Terms and definitions
- 4 Principle
- 5 Reagents and materials
- 5.1 General
- 5.2 MAP reagent
- 5.3 Reagent solutions
- 5.3.1 Impinger solution
- 5.3.2 Solution for filter impregnation
- 5.3.3 Filter extraction solution
- 5.3.4 Stability of reagent solutions
- 5.4 Standard matching solutions
- 5.4.1 General
- 5.4.2 Preparation of monomer derivatives
- 5.4.3 Preparation of standard solutions of monomer derivatives for HPLC analysis
- 5.4.4 Preparation of monomer derivatives for solid-phase extraction (SPE)
- 5.4.5 Preparation of derivative solutions of bulk isocyanate products
- 5.5 HPLC mobile phase
- 5.5.1 General
- 5.5.2 Mobile phase buffer solutions
- 5.5.3 Primary mobile phases
- 5.5.4 Post-column acid mobile phase
- 6 Apparatus
- 6.1 General
- 6.2 Sampler
- 6.2.1 General
- 6.2.2 Filters
- 6.2.3 Midget impingers
- 6.3 Sampling pump
- 6.4 Tubing
- 6.5 Flowmeter
- 6.6 Filtration and solid-phase extraction equipment
- 6.7 Liquid chromatographic system
- 6.7.1 Autosampler
- 6.7.2 Pumping system
- 6.7.3 Analytical column
- 6.7.4 Column oven
- 6.7.5 Post-column acid delivery pump
- 6.7.6 Detectors
- 7 Air sampling
- 7.1 Pre-sampling laboratory preparation
- 7.1.1 Cleaning of sampling equipment
- 7.1.2 Preparation of MAP-coated filter samplers
- 7.1.3 Preparation of extraction solution jars
- 7.2 Pre-sampling field preparation
- 7.2.1 Calibration of pump
- 7.2.2 Preparation of samplers
- 7.3 Collection of air samples
- 7.3.1 Filter sampling
- 7.3.2 Impinger sampling
- 7.3.3 Sampling with an impinger followed by a filter
- 7.4 Blanks and negative controls
- 7.5 Bulk products
- 7.6 Shipment of samples
- 7.7 Filter test samples
- 7.8 Impinger test samples
- 8 HPLC analysis
- 8.1 Instrumental settings
- 8.2 HPLC programme
- 9 Data handling
- 9.1 Monomer measurement
- 9.2 Oligomer measurement (total detectable isocyanate)
- 10 Calibration and quality control
- 10.1 Standard matching solutions
- 10.2 Calibration curves
- 10.3 Blank tests
- 10.4 Bulk products
- 10.5 Quality control spikes
- 11 Calculations
- 11.1 Monomer
- 11.2 Oligomers (total detectable isocyanate)
- 12 Interferences
- 13 Determination of performance characteristics
- 13.1 General
- 13.2 Assessment of performance characteristics
- 13.2.1 Collection efficiency relative to particle size distribution
- 13.2.2 Air sampling
- 13.2.3 Analysis
- 13.2.4 Mass of compound in sample blank
- 13.2.5 Between-laboratory uncertainty contributions
- 13.2.6 Combined uncertainty
- 13.2.7 Expanded uncertainty
- 13.2.8 Uncertainty from performance criteria
- Annex A (informative) Performance characteristics
- Bibliography [Go to Page]